The interrater reliability was evaluated by using κ statistics. The patients came from 4 centers in Europe, and the scans were rated by 4 raters on 1 occasion with the new ARWMC rating scale. Methods-Seventy-seven patients with ARWMC on either CT or MRI were recruited and a complementary examination (MRI or CT) performed. We have developed and evaluated a new scale and studied ARWMC in a large number of patients examined with both MRI and CT. To be able to study the evolution and possible effect of drug treatment on ARWMC in large patient samples, it is necessary to have a rating scale constructed for both MRI and CT. This makes it difficult to compare CT and MRI studies. Most rating scales estimate the degree and distribution of ARWMC either on CT or on MRI, and they differ in many aspects. Customer Service and Ordering Informationīackground and Purpose-MRI is more sensitive than CT for detection of age-related white matter changes (ARWMC).Stroke: Vascular and Interventional Neurology. Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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